席建忠
教育经历：
1996年，北京理工大学攻读化工专业，本科
2000年，清华大学攻读分子细胞生物，硕士
2004年，UCLA生物医学工程，博士
背景资料：
席建忠，北京大学工学院，研究员，博士生导师，“国家杰出青年基金”资助。1996年毕业于北京理工大学化工与材料学院，2000年在清华大学生物系获得细胞与分子生物学硕士，2004年在加州大学洛杉矶分校获得生物医学工程专业博士学位。2005年，加入北京大学工学院生物医学工程系。目前担任中国化学会化学生物学专业委员会委员、中国医药生物技术协会生物芯片分会常务委员、中国生物医学工程学会生物医学测量分会委员等职务。
研究方向：主要从事大规模功能基因技术的研发和应用，包括细胞芯片、大规模药物筛选、基因操纵、miRNA、TALE及CRISPR技术开发和应用等。近五年，围绕药物筛选、药效评估动物模型等方面，取得了突出成绩，在 Nature, Nature Biotechnology, Nature Cell Biology, Nature Communication, PNAS, Angew. Chem. Int. Ed., 等专业杂志，发表 30余篇高水平学术论文；主持或承担过国家自然科学基金 4项，973课题 2项及863课题2项。
获得荣誉：
1. 国家自然科学基金委杰出青年 2013
2. 李氏基金，2006年
3. "2004 National Outstanding Overseas Graduate Students"，Chinese Education Ministry (2005)
4. "Outstanding Doctoral Graduate Student", UCLA (2004)
5. "Best Young Student/Investigator" 2004 MRS Spring Meeting
6. News articles regarding my achievement in Science, Nature, CNN, BBC, LA times, etc.
近年来发表论文:
1. Haisong Liu, Huan Yang, Dicong Zhu, Xin Sui, Juan Li, Zhen Liang, Lei Xu, Zeyu Chen, Anzhi Yao, Long Zhang, Xi Zhang, Xing Yi, Meng Liu, Shiqing Xu, Wenjian Zhang, Hua Lin, Lan Xie, Jinning Lou, Yong Zhang, Jianzhong Xi *, Hongkui Deng*, Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells, Cell Research 20: 1181-1200, 2014
2. Zhang H, Li J, Hou S, Wang G, Jiang M, Sun C, Hu X, Zhuang F, Dai J*, Xi J*, Engineered TAL Effector Modulators for the Large-scale Gain-of-Function Screening, Nucleic Acid Research 42(14):e114, 2014
3. Hao Y, Yang J, Yin S, Zhang H, Fan Y, Sun C and Xi J*. The Synergistic Regulation of VEGF-mediated Angiogenesis Through miR-190 and Target Genes, RNA, 20, 1-9, 2014
4. Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong Y-N, Peng X, Xi J, Chen S, Wang F & Shao F, Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome, Nature 513(7517):237-41, 2014
5. Fan Y, Yin S, Hao Y. Yang J, Zhang H, Sun C, Ma M, Chang Q, and Xi, J*. miR-19b promotes tumor growth and metastasis via targeting TP53, RNA, 20(6):765-72, 2014
6. Ji D, Chen Z, Li M, Zhan T, Yao Y, Zhang Z, Xi J, Yan L, Gu J, MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1 Molecular Cancer 13:86, 2014
7. Yi Zhang, Lu Zhang, Jiashu Sun, Yulei Liu, Xingjie Ma, Shangjin Cui, Liying Ma, Jianzhong Jeff Xi, Xingyu Jiang. Point-of-Care Multiplexed Assays of Nucleic Acids Using Microcapillary-based Loop-Mediated Isothermal Amplification, Analytical Chemistry 86: 7057-7062, 2014
8. Ren X, Sun J, Housden B.E, Hu Y, Roesel C, Lin S, Liu L-P, Yang Z, Mao D, Sun L, Wu Q, Ji J-Y, Xi J, Mohr S, Xu J, Perrimon N, Ni J-Q, Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9, Proceedings of the National Academy of Sciences 110:47 19012-19017, 2013
9. Shan Q, Wang Y, Li J, Zhang Y, Chen K, Liang Z, Zhang K, Liu J, Xi J, Qiu J-L, Gao C*, Targeted Genome Modification of Crop Plants Using the CRISPR/Cas System, Nature Biotech. 31, 686, 2013
10. Zhang H, Wu PY, Ma M, Ye Y, Hao Y, Yang J, Yin S, Sun C, Phan JH, Wang MD*, Xi J *. An integrative approach for the large-scale identification of human genome kinases regulating cancer metastasis, Nanomedicine 9(6):732-6, 2013
11. Chen J, Ma M, Shen N, Xi J*, Tian W*. Integration of cancer gene co-expression network and metabolic network to uncover potential cancer drug targets, J Proteome Res. 12(6):2354-64, 2013
12. Zhang Y, Qiao L, Ren Y, Wang X, Gao M, Tang Y, Xi J, Fu T-M, Jiang X, Two dimensional barcode-inspired automatic analysis for arrayed microfluidic immunoassays, Biomicrofluidics 7, 034110, 2013
13. Chang N, Sun C, Gao L, Zhu D, Xu X, Zhu X, Xiong J-X*, and Xi J*. Genome Editing via the RNA-guided Cas9 Nuclease in Zebrafish Embryos, Cell Research, 23(4):465-72, 2013
14. Rong Y, Liu M, Ma L, Du W, Zhang H, Tian Y, Li Y, Ren H, Zhang C, Li L, Chen S, Xi J* & Li Yu*, Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation, Nature Cell Biology 14(9):924-34, 2012
15. Zhao Wang, Juan Li, Gancheng Wang, Mingjun Jiang, Shenyi Yin, Changhong Sun, Hanshuo Zhang, Fengfeng Zhuang* and Jianzhong Jeff Xi*, An Integrated Chip for the High-throughput Synthesis of Transcription-Activator-like Effectors, Angew. Chem. Int. Ed., 124:34, 8633-8636, 2012
16. Ming Xu, Hao-Di Wu, Rong-Chang Li, Hai-Bo Zhang, Meng Wang, Jin Tao, Xin-Heng Feng, Yun-Bo Guo, Su-Fang Li, Shao-Ting Lai, Peng Zhou, Lin-Lin Li, Hua-Qian Yang, Guan-Zheng Luo, Yan Bai, Jianzhong J. Xi, Wei Gao, Qi-De Han, You-Yi Zhang, Xiu-Jie Wang, Xu Meng*, Shi-Qiang Wang*. Mir-24 Regulates Junctophilin-2 Expression in Cardiomyocytes, Circulation Research, 111: 837-841, 2012
17. Ping Yin, Dong Deng, Chuangye Yan, Xiaojing Pan, Jianzhong Jeff Xi, Nieng Yan, and Yigong Shi*. Specific DNA-RNA Hybrid Recognition by TAL Effectors, Cell Reports, 2(4):707-13, 2012
18. Yi Zhang, Xuwei Wang, Lusheng Song, Chuanlai Xu, Liying Ma, Zhanhua Li, Jianzhong Xi* and Xingyu Jiang*. Matrix-localization for fast analysis of arrayed microfluidic immunoassays, Anal. Methods, 4, 3466, 2012
19. Zhao Wang, Huang Huang, Hanshuo Zhang, Chang Hong Sun, Yang Hao, Junyu Yang, Yu Fan, and Jianzhong Xi*, A Magnetic Bead-Integrated Chip for the Large Scale Manufacture of Normalized esiRNAs, PLoS ONE, 7(6): e39419, 2012
20. Junyu Yang, Yang Hao, Jianzhong Jeff Xi*. Therapeutic Application of MicroRNAs against Human Cancers, J Lab Autom., Feb;18(1):30-3, 2012
21. Hanshuo Zhang, Yang Hao, Junyu Yang, Ying Zhuo, Juan Li, Changhong Sun, Shenyi Yin, Yanyi Huang and Jianzhong Xi*, Genome-wide Functional Screening of miR-23b as a Pleiotropic Modulator Suppressing Cancer Metastasis, Nature Communications, 2:554, 2011
22. Huang Huang, Qing Chang, Changhong Sun, Shenyi Yin, Juan Li and Jianzhong Xi*, A polyacrylamide microbead-integrated chip for the large-scale manufacture of ready-to-use esiRNA, Lab on a Chip, 11(6): 1036-1040, 2011
23. Huiping Yuan, Xiaoyong Zhang, Xiuqing Huang, Yonggang Lu, Weiqing Tang, Yong Man, Shu Wang, Jianzhong Xi* and Jian Li*, NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of b-Cells via JNK, p38 MAPK and p53 Pathways, PLoS ONE, 5(12): e15726, 2011
24. Yu Z, Zhu Y, Zhang Y, Li J, Fang Q, Xi J, Yao B*. Nanoliter droplet array for microRNA detection based on enzymatic stem-loop probes ligation and SYBR Green real-time PCR, Talanta, 85(4):1760-5, 2011
25. Smith AH, Robinson EM, Zhang XQ, Chow EK, Lin Y, Osawa E, Xi J and Ho D. Triggered release of therapeutic antibodies from nanodiamond complexes, Nanoscale, 3(7):2844-8, 2011
26. Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, Li YS, Chien S*, Wang N*. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells, Proc Natl Acad Sci USA., 107(7):3240-4, 2010
27. Li J, et al. Jianhzhong Xi*, Wang X*, Real-Time Polymerase Chain Reaction MicroRNA Detection Based on Enzymatic Stem-Loop Probes Ligation, Anal. Chem., 81: 5446-5451, 2009
28. Wang J,et al. Xi J*, Huang Y*, A Chip-to-chip Nanoliter Microfluidic Dispenser. Lab on a Chip, 9:1831-1835, 2009
29. Yao B, Li J, et al. Xi J*, Quantitative analysis of zeptomole microRNAs based on isothermal ramification amplification, RNA 15: 1787-1794, 2009
30. Xu Ji, Zhihong Li, Jianzhong Xi, Juan Li, Yangyuan Wang, A piezoresistive cantilever for lateral force detection fabricated by a monolithic post-CMOS process, Journal of Micromechanics and Microengineering, 11: 1-11, 2008
31. Xi J*, Jacob J, Montemagno C, Self-assembled microdevices driven by muscle, Nature Materials 4:180-184, 2005
32. Xi Jianzhong*, Ho Dean, Chiu Ben, Montemagno Carlo, Lessons learned from engineering biologically-active hybrid nano/micro-devices，Advanced Functional Materials, 15,1233-1240, 2005
33. Qiong Wu, Zhong Zheng, Jianzhong Xi, Haijun Gao and Guo-qiang Chen, Production of Hydroxyalkanoate Monomers by Microbial Fermentation. Journal of Chemical Engineering of Japan, 36: 1170-1173, 2003
340 Jianzhong Xi, Qiong Wu , Yongbin Yan, Zengming Zhang, Peter H.F Yu, Man-ken Cheung, Riqing Zhang and Guoqiang Chen. Hyperproduction of polyesters consisting of medium-chain-length hydroxyalkanoate monomers by strain Pseudomonas stutzeri 1317. Antonie van Leeuwenhoek, 78: 43-49, 2000
35. Chen Guoqiang, Wu Qiong, Xi Jianzhong and Yu H.Peter. Microbial production of biopolyesters-polyhydroxyalkanoates, Progress of Natural Sciences, 10: 843-850, 2000
近年来专利申请情况:
1. 席建忠，姚波，李娟 用于小RNA检测的探针组以及用此探针组检测小RNA的方法，中国，发明专利 （审批中）
2. 黄岩谊，席建忠，王建斌，周莹 微流分配装置、其制备方法及用途，中国，发明专利（审批中）
联系方式：
Biomedical Engineering, College of Engineering, Peking University, 100871
Email: xi at coe.pku.edu.cn
职位信息（长期有效）：
招聘 2 名研究助理或博士后。有意应聘者请将个人简历和工作背景简介发送到个人Email: xi at coe.pku.edu.cn，谢绝来电询问。来信主题请注明“应聘研究助理或博士后职位”。待遇面谈。