● 香港大学Jennifer Man-Fan Wan 副教授讲座通知（2017-3-6）
Title：Cell-Cycle Specific Anticancer Mechanisms of Chinese Medicinal Mushrooms and Dietary lipids: Flow Cytometric Analyses
报告人：Jennifer Man-Fan Wan (Associate Professor, The University of Hong Kong)
主持人：陈峰 教授
时间：2017年3月6日(周一)下午1:00-2:00
地点：工学院1号楼210会议室
报告内容摘要：
Unhealthy diets and lifestyle are known determinants for the leading risk of cancer and death globally. The present talk aims to discuss the cancer preventive mechanisms of natural products, specifically, the Chinese medicinal Mushrooms and Dietary lipids.
She will present her findings to show the anticancer and immunological mechanisms of the polysaccharides peptide (PSP) isolated from the Chinese Medicinal Mushroom “Yun Zhi” from Coriolus versicolor on human leukemic cells. Their data points to the S-phase cell cycle specific mechanism of PSP as well as its specific impacts on the Th1 and Th2 cytokines capable of balances the human T-lymphocytes homeostasis. The anticancer mechanisms diet high in omega-3 polyunsaturated fatty acids and omega-9 monunsaturated fatty acids in animal models will also be discussed.
报告人简介：
Dr. Jennifer Wan
Associate Professor
School of Biological Sciences
The University of Hong Kong
Hong Kong, SAR
jmfwan
hku.hk
Dr. Jennifer Wan, an Associate Professor at the School of Biological Sciences, The University of Hong Kong, has obtained her Bsc degree from the University of London in 1983 and received her doctoral degree in 1987 from the University of Southampton, in England. Dr. Wan worked as Research Associate at the department of Surgery and later on at the department of Medicine of the Harvard Medicine School, Boston, and USA for more than 7 years. Since 1993, Dr Jennifer Wan has been engaged in teaching and research in nutrition and public health, diet and disease and food science at the University of Hong Kong. But her real passion is on the promotion of research and development of Traditional Chinese Medicine (TCM) to the West. In 2003, Dr. Jennifer Wan has decided to get her second Bsc degree, in Traditional Chinese Medicine (TCM), from the Traditional Chinese Medicine of the University of Beijing, China. Since then, Dr Wan has applied flow cytometry technology for cancer and immunity research and the “Omics” technology for biomarkers discovery and mechanistic pathways identification on both the principles and applications of TCM. She is the author and co-author of over 80 articles in international journals, book chapters and has supervised more than 20 research postgraduate students. She is proactive in both Teaching and Research in Chinese Medicine.
● 北京大学邹鹏特聘研究员讲座通知（2016-4-28）
题目：Mapping the Subcellular Proteome via APEX Labeling
报告人：邹鹏 博士（北京大学化学与分子工程学院特聘研究员）
主持人：刘进 特聘研究员
时间：2016年4月28日(周四)上午10:00
地点：工学院1号楼210会议室
报告内容摘要：
Dr Zou will introduce a new technology that offers spatially-resolved proteomic maps of living cells. The method relies on an engineered peroxidase enzyme, APEX, that biotinylates nearby proteins, which are subsequently purified and identified by mass-spec. We used this approach to identify proteins residing within the human mitochondrial matrix and the inter-membrane space. The labeling was exceptionally specific and led to the discovery of several novel mitochondrial proteins, including two key players in the heme biosynthesis pathway, which challenged the textbook model of how this pathway operates. The specificity of live-cell peroxidase-mediated proteomic mapping combined with its ease of use offers biologists a powerful tool for understanding the molecular composition of living cells.
报告人简介：
邹鹏，2007年本科毕业于北京大学化学与分子工程学院，获化学学士和物理学学士双学位。2012年获美国麻省理工学院化学博士学位。2013年至2015年在哈佛大学化学与化学生物学系进行博士后工作。2015年5月起任北京大学化学与分子工程学院特聘研究员，兼任北大-清华生命科学联合中心和IDG/麦戈文脑科学研究所研究员。邹鹏博士致力于发展化学探针技术，实现对神经细胞高时空分辨的定量观测。他的课题组综合运用蛋白质工程、分子生物学和有机合成等手段创造新的功能分子，包括各类荧光探针、具有特殊活性的酶等；同时结合光学、质谱学等仪器技术，利用这些工具观测神经系统的结构与功能，并通过数学建模对数据进行定量分析。
● 暨南大学李宏业教授讲座通知（2015-10-26）
题目：海洋微藻脂类代谢及高值化利用
报告人：李宏业 教授（暨南大学生命科学技术学院，水体富营养化与赤潮防治广东省重点实验室）
主持人：刘进 特聘研究员
时间：2015年10月27日(周二)下午15:00
地点：力学楼434会议室
报告内容摘要：
微藻脂类物质含量及成分直接影响着微藻在水产、医药、能源等领域的应用，是微藻资源利用中的重要指标。受限于对微藻脂质合成代谢流的调控机制和限制步骤的认知不够，相关微藻藻株改良研究的进展缓慢。我们针对海洋微藻脂质代谢开展研究，借鉴其他物种的脂质代谢的基础理论及研究成果，围绕提高微藻脂类物质合成与累积进行研究。构建了目标微藻的遗传转化体系，对微藻脂质代谢网络的途径进行解析，发掘了其中的潜在关键节点，包括调控脂质合成、降解、脂质组分等的调控节点，对相关的关键酶的功能、该基因的表达调控模式进行了深入分析，初步阐明脂质形成的分子基础，提升了对微藻脂质代谢网络的认知，并建立了微藻脂质代谢相关藻株改良的分子生物学数据库和基因资源库，为微藻高值化利用提供理论依据。
报告人简介：
李宏业教授2003年在香港大学获博士学位，2008年底加入暨南大学水生生物学国家重点学科，开始从事海洋微藻遗传及代谢机理的研究，率先建立了褐指藻等代表性藻种的高效电击遗传转化体系，在微藻脂质代谢机理方面取得了系列原创性成果。发现并阐明了微藻胞内膜脂重塑机制，解析了脂质高水平累积的来源，揭示了其中潜在关键节点在脂质累积中的独特作用及调控机理。发现了微藻氮磷营养盐吸收利用相关的一些关键酶及调控因子，初步揭示了其调控模式。成果为微藻高值化利用提供了理论基础。相关成果发表在Metabolic Engineering、Environmental Microbiology、Biotechnology for Biofuels、Algal Research、Marine Biotech等权威期刊。主持国家自然科学基金、科技部科技支撑计划课题、973项目子课题、广东省自然科学基金重大项目等10余项省部级以上项目；微藻脂质代谢研究成果获广东省第四届南粤科技创新优秀论文一等奖。
● 英国赫尔大学教授Colin Ratledge讲座通知（2015-10-13）
题目：Microorganisms as sources of valuable oils
报告人：Prof. Colin Ratledge
主持人：Steven Feng Chen (陈峰), Professor
时间：2015年10月23日(周五)上午10:30
地点：工学院1号楼210会议室
报告人简介：
Professor Ratledge is recognized as a world authority on the production of single cell oils, particularly the production of polyunsaturated fats by yeast, fungi and algae. Professor Ratledge has conducted extensive research in the biochemistry of the formation of arachidonic acid (ARA) and related polyunsaturated fatty acids by Mortierella fungi (supported by BBSRC), as well as the formation of docosahexaenoic acid (DHA) and related polyunsaturated fatty acids by the marine algae Crypthecodinium cohnii (supported by EU). He has worked extensively on the genetic control of key genes involved in lipid accumulation and the biochemistry and regulation of acetyl-CoA in microorganisms. From 1964-1967 he was a research scientist at Unilever Research Laboratory, and since 1967 has been on staff at the University of Hull, where he has been professor and head of the Biochemistry Department. He is a Fellow of the Royal Society of Chemistry, and a Fellow of the Institute of Biology. Professor Ratledge has published more than 200 peer-reviewed research papers, edited or co-edited 16 books, and written more than 80 review articles. He is a member of the editorial board for Enzyme and Microbial Technology, Biometals, Lipid Technology, and Lipid Technology Newsletter. He is Associate editor of Lipids, as well as Editor in Chief of World Journal of Microbiology and Biotechnology, in addition to Biotechnology Letters. He has been a member of the Science Advisory Committee of the European Federation of Biotechnology (1983-87), Vice Chairman of the British Coordinating Committee for Biotechnology (1986-91, including Chairman 1989-91), and a member of the Management Committee of the Advanced Centre for Biochemical Engineering, University College London (1996 to present). Professor Ratledge holds a Ph.D. in Biochemistry from Manchester University's College of Science and Technology.
Email: c.ratledge
hull.ac.uk
● 美国马里兰大学Yantao Li博士讲座通知（2015-6-17）
题目：Triacylglycerol and carotenoid synthesis in microalgae: pathways and biotechnological implications
报告人：Yantao Li, Assistant Professor
主持人：Steven Feng Chen (陈峰), Professor
时间：2015年6月17日（周三）上午10:00
地点：工学院1号楼212会议室
报告人简介：
Yantao Li is an Assistant Professor of Institute of Marine and Environmental Technology at the University of Maryland. His research interest is in the area of algal biology and biotechnology, in which the goal is to understand lipid synthesis, turnover, and lipid body biogenesis in microalgae, to rationally engineer algae for biofuel and high-value products such as carotenoids, and to biochemically convert algal feedstock into biofuels. Dr. Li has over 20 scientific publications in the algal biotechnology field. Dr. Li received his Ph.D. degree in Microbial Biotechnology from the University of Hong Kong in 2007 and B.S. degree in Plant Biology from Nanjing University in 2002.
(For more information, please visit http://www.umces.edu/imet/people/yantao)
Email: yantao
umces.edu
● 澳大利亚昆士兰大学Lars Nielsen教授讲座通知（2015-3-12）
题目：Genome scale metabolic and regulatory network modelling in higher eukaryotes
报告人：Lars Nielsen, Professor
主持人：Steven Feng Chen (陈峰), Professor
时间：2015年3月16日(周一)10:00
地点：工学院1号楼212会议室
报告内容摘要：
Implicit in the collection of high-throughput data is an assumption that computational models ultimately will facilitate biological discovery, reconciliation of heterogeneous data types, identify inconsistencies and enable the systematic generation of hypotheses. Current naïve statistically models falls well short of this ambition, while the use of the conventional dynamic models of physics suffers from our inability to accurately determine in vivo parameters. Constraint based models use stoichiometry, thermodynamics, physical capacity constraints and regulation to define feasible solution spaces, which can then be explored using a range tools to infer network behaviour. The framework has proven surprisingly powerful in its ability to predict the behaviour of natural as well as engineered networks in microbes.
Higher eukaryotes present additional challenges in the form of (a) compartmentalised metabolism with difficult to identify intracellular transporters and pathway duplication, (b) complex genome regulation, (b) multicellularity and associated difficulty in defining objectives, and (d) difficulty of reliable manipulation and analysis at cellular level. However, the same challenges that make higher eukaryotic systems less tractable also makes the potential advantage of model based analysis far greater. In this presentation, I will discuss a range of mathematical and experimental approaches we use to identify and constrain the degrees of freedom in animal and plant genome scale models to make them more tractable. The aim is to - at a minimum - make explicit the assumptions made in more practical, reduced models and - ideally - develop controls for these assumptions.
报告人简介：
Professor Nielsen heads the Systems and Synthetic Biology Group at the Australian Institute for Bioengineering and Nanotechnology. Using thermodynamic principles, novel approaches are developed for the rational design of complex pathways as well as handling complex, transient dynamics in developing tissue. A team of 40 people use these novel approaches in the design of bioprocesses as diverse as the production of blood cells for transfusion and the production of industrial biopolymers. Professor Nielsen also heads the Metabolomics Australia Queensland Node, which is focused on assisting Australian scientists developing flux modeling and analysis approaches for their biological systems of interest
(For more information, please visit http://www.aibn.uq.edu.au/?page=33694)
Email: lars.nielsenuq.edu.au
● 美国俄亥俄州立大学杨尚天（Shang-Tian Yang）教授讲座通知（2014-12-2）
题目： Comparative genomic analysis and metabolic engineering of Clostridium acetobutylicum for enhanced butanol tolerance and production
报告人：Shang-Tian Yang (杨尚天), Professor
主持人：Steven Feng Chen (陈峰), Professor
时间：2014年12月5日(周五)10:00
地点：工学院1号楼210会议室
报告人简介：
Shang-Tian Yang is Professor of Chemical and Biomolecular Engineering at the Ohio State University and the Director of Ohio Bioprocessing Research Consortium, which works with industry in developing novel bioprocesses for economical production of value-added products from food processing wastes and agricultural commodities. Dr. Yang has over 180 scientific publications and a dozen of US patents in the bioengineering field. He is the editor of the book “Bioprocessing for Value-Added Products from Renewable Resources: New Technologies and Applications” published by Elsevier in 2007. He is also a co-founder of two biotechnology startup companies. Dr. Yang is an elected fellow of American Institute of Medical and Biological Engineering and an active member of American Institute of Chemical Engineers (AIChE) and American Chemical Society (ACS). He also serves as an Associate Editor for the journal Process Biochemistry. Dr. Yang received his Ph.D. degree in Biochemical Engineering from Purdue University in 1985 and B.S. degree in Agricultural Chemistry from National Taiwan University in 1976.
(For more information, please visit https://cbe.osu.edu/people/yang.15)
Email: yang.15osu.edu
● 德国法兰克福大学Gerhard Sandmann教授学术报告通知（2014-04-20）
题目：Carotenoid biosynthesis and genetic pathway engineering
报告人：Gerhard Sandmann, Professor
时间：2014年4月23日15:10
地点：北京大学二教210室
报告人简介：
Gerhard Sandmann教授早年先后在德国美因茨大学（University of Mainz）和法兰克福大学（University of Frankfurt）学习生物学和化学，博士期间研究方向为植物生理学领域里真菌的代谢机制研究，博士后研究在德国康斯坦茨大学（University of Konstanz）研究植物和藻类中富含金属离子的酶类。1987年确立了其在植物生理学和生物化学领域的研究地位，1993年起任法兰克福大学全职教授。Gerhard Sandmann教授在植物生理学和生物化学，类胡萝卜素的生物合成、代谢及其调控，应用代谢工程技术改造不同生物的生物合成等方面成果显著：阐明了不同生物类胡萝卜素的生物合成及其进化；阐释了类胡萝卜素的代谢与调控机制，重点为生物合成中单独反应所涉酶类的基因表达调控；利用酶动力学研究探索了代谢过程中单一反应的机制；利用高效液相色谱和质谱等方法发现并鉴定了系列新型类胡萝卜素及其分子结构；利用基因工程手段将植物和菌类中类胡萝卜素生物合成基因导入其它生物来提高合成效率。已发表SCI研究论文100余篇。
Email: sandmannbio.uni-frankfurt.de
● 江南大学詹晓北教授学术报告通知（2014-03-11）
题目：高级生化工程-微生物多糖发酵技术及高粘度生物反应器设计
报告人：詹晓北 教授
时间：2014年3月12日15:10
地点：北京大学二教210室
报告人简介：
詹晓北教授1983年毕业于无锡轻工业学院工业发酵专业并获学士学位，1987年获无锡轻工业学院发酵工程专业硕士学位，留校后一直从事高粘度反应器和微生物多糖的研究。留学美国期间从事利用农产品生物转化工程及其装备技术的研究，获堪萨斯州立大学农业与生物工程专业博士学位。现为江南大学教授、博士生导师、生物化工系主任和学科带头人。2005年获国家注册化工工程师资格证书，2006年入选“无锡市学术技术带头人”培养工程。社会兼职为美国ASAE和IFT学会会员。 其研究领域为高粘度发酵技术、微生物多糖生物合成、功能性寡糖制备、生物反应器及传统发酵食品。
詹晓北教授从事教学和科研工作20多年来，一直致力于工业发酵与生化工程领域的学术探索，负责江南大学生物化工领域的学科发展规划与学术梯队建设，近年来先后承担“国家支撑计划”、“863计划”、“国家自然科学基金”等多项国家及省市级科研基金项目。出版专著1篇，发表学术论文90余篇，其中SCI/EI收录30余篇；申请专利20项，授权9项；完成项目鉴定10多项，成果获奖4项。其长期从事系列食品用微生物多糖的发酵生产、功能开发与应用研究，在微生物多糖的生产与应用领域经验丰富，部分成果达到国际领先水平，建立了国内较知名的微生物多糖实验室，与国际知名的糖科学研究机构及学者专家合作交流紧密，并在多糖产品及糖化学技术成果转化方面积累了丰富的经验。主持参与的项目成果“食品级微生物多糖发酵生产关键技术”获2010年度中国食品科学技术学会科技进步三等奖。另外，詹晓北教授积极从事科技开发工作，参加转让科研项目和参加工程设计工作，有很强的设计能力和工程技术实施的现场经验。拥有国家注册化工师资格证书，具有良好的项目实施能力，对产品的成果转化具有丰富的经验。曾完成多项生产工厂设计，并自主设计和研制出高效传质并适用于高粘度发酵体系的生物反应器，获得科技进步三等奖。
● 清华大学邢新会教授学术报告通知（2013-03-29）
题目：Bioprocess Integration Inspired by Life Evolution and Organisation
报告人：邢新会 教授
时间：2013年4月2日15:10
地点：北京大学二教318室
报告人简介：
邢新会教授是第十届和第十一届全国政协委员，清华大学化工系“百人计划”教授，博士生导师，生物化工研究所所长，医学研究院药物研究所副所长。担任中国化工学会生物化工专业委员会委员，中国微生物学会酶工程专业委员会委员，北京市生物加工重点实验室学术委员，国内核心刊物《食品与生物技术学报》、《生物产业技术》和《食品科学》编委，国际学术期刊《Biochemical Engineering Journal》副主编，国际学术期刊《Journal of Molecular Catalysis B: Enzymatic》、《Enzymatic and Microbial Technology》和《Journal of Biological Engineering》编委。
目前，在微生物修复技术、高效废水生物处理技术、生物制氢的代谢工程、氢酶及甲烷单加氧酶、荧光蛋白基因的应用、融合蛋白技术及原位荧光杂交技术等方面开展了深入的研究，取得了一系列科研成果。其中研究剩余污泥减量化废水生物处理技术已开始在工业中得到应用，融合肝素酶的工业生产及其规模化制备低分子肝素技术进入中试阶段。申请到国家自然科学基金面上和国际合作项目、自然科学基金重点项目、博士点基金及教育部优秀青年教师资助计划、国家”十五“攻关和“十一五”科技支撑计划资助课题、973和863计划项目、中石油集团及其他国内外企业合作项目等多项课题。到目前为止，已在国际、国内学术刊物和国际会议上发表论文220余篇(其中SCI收录70余篇，EI收录50余篇)，合作著书7本，译著教材2部，申请发明专利30余项，获得发明专利5项。曾于1993年获得日本财团法人手岛工业教育基金团研究纪念奖；于2002年获得清华大学第五届”良师益友”荣誉称号；于2004年获得日本竹田国际交流（生物工程领域）贡献奖；于2007年获得第17届全国发明展览会奖银奖。
● 美国俄亥俄州立大学杨尚天（Shang-Tian Yang）教授讲座通知（2012-12-11）
题目：Engineering Clostridial Fermentation for Biofuels and Chemicals Production
报告人：Shang-Tian Yang, Professor
时间：2013年1月8日14:00
地点：工学院1号楼210会议室
报告内容摘要：
This presentation will focus on the recent progress in metabolic engineering of Clostridia for economical production of biofuels, including butanol from renewable biomass. Butanol is an important industrial solvent and potentially a better transportation fuel than ethanol. Currently, butanol is almost exclusively produced via petrochemical routes. Biobutanol will have a great potential to compete with ethanol as a transportation fuel when its production cost is reduced by using advanced fermentation technologies such as metabolically engineered Clostridia mutants. Conventional acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum or C. beijerinkii is severely limited by its poor butanol yield (<0.25 g/g glucose), low productivity (<0.5 g/L栠), low final butanol concentration (<15 g/L), and poor process stability. Recently, we have developed several metabolically engineered mutant strains of clostridia for butanol production. A novel solventogenic Clostridium was developed by introducing butanol biosynthesis pathway and blocking acid producing pathways in non-solventogenic acid-forming Clostridium tyrobutyricum which has relatively simple metabolic pathways with high flux toward butyryl-CoA, the precursor for butanol biosynthesis, and high butanol tolerance. A high butanol titer of >16 g/L with a high butanol yield of 0.33 g/g substrate were obtained in batch fermentation. In addition, we have also developed a mutant strain of Clostridium acetobutylicum with high butanol tolerance and productivity through evolutionary engineering in a fibrous bed bioreactor (FBB). The high butanol tolerant strain JB200 can produce up to 21 g/L butanol in conventional free-cell fermentation and 28.2 g/L butanol in the FBB fermentation. When the mutant strain is used in fermentation coupled with continuous gas stripping for in situ butanol recovery, high butanol productivity and yield can be achieved with an extremely high butanol titer of >150 g/L in the gas stripping condensate that can be easily purified with a low energy input.
报告人简介：
Shang-Tian Yang is Professor of Chemical and Biomolecular Engineering at the Ohio State University and the Director of Ohio Bioprocessing Research Consortium, which works with industry in developing novel bioprocesses for economical production of value-added products from food processing wastes and agricultural commodities. Dr. Yang has over 180 scientific publications and a dozen of US patents in the bioengineering field. He is the editor of the book “Bioprocessing for Value-Added Products from Renewable Resources: New Technologies and Applications” published by Elsevier in 2007. He is also a co-founder of two biotechnology startup companies. Dr. Yang is an elected fellow of American Institute of Medical and Biological Engineering and an active member of American Institute of Chemical Engineers (AIChE) and American Chemical Society (ACS). He also serves as an Associate Editor for the journal Process Biochemistry. Dr. Yang received his Ph.D. degree in Biochemical Engineering from Purdue University in 1985 and B.S. degree in Agricultural Chemistry from National Taiwan University in 1976.
Email: yang.15osu.edu
https://cbe.osu.edu/people/yang.15
